Leonurus is a plant, but also a traditional Chinese medicine, Leonurine has a long history, especially for the treatment of women’s disease, such as the treatment of irregular menstruation, postpartum diseases and so on, can also play the beauty of beauty, acne efficiency, deeply loved by women friends.
Toxic and side effects
The toxicity of Leonurus was very low. The injection of Leonurus Leonuri injection to mice was 30 ~ 60g, and the total alkaloid of Leonurus Leonuri was injected into the mice by intravenous injection, and half of the lethal dose was 572.2 + 37.2mg. Leonurine in the abdominal cavity, and each time was 2mg for 4 days without obvious adverse reaction. The total alkaloid of Leonurus Leonuri was injected 30mg/d under rabbit skin for 2 weeks. No significant effect was observed on food, body temperature and defecation. Feeding with 50% motherwort powder feed to adult rats for 80 days did not show toxicity or fertility change.
The role of the cardiovascular system
Low dose of Herba Leonuri increased contractility in isolated frog heart, and inhibited it in a large dose. This inhibition may be due to the excitation of vagal nerve terminals. Use of Leonurine (2mg) injection in the intravenous anesthesia of the cat, that is, the drop of blood pressure, a few minutes after the recovery, this moment temporary blood pressure drop phenomenon, after the vagotomy of the vagus can still be found, if the first use of atropine, and then injection of Leonurine, the blood pressure drop is not as significant as before, it can be known that Leonurine. The effect of lowering blood pressure is not caused by vagotomy, but may be stimulated by vagal nerve terminals.
The role of the respiratory center
Herba Leonuri had direct excitation, and the respiratory frequency and amplitude increased significantly after intravenous injection of Leonurus alkaloids in cats, but at large doses, respiration was turned from excitement to inhibition and became weak and irregular. After cutting off both sides of the nerve, there is still no respiratory excitation.
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