Berberine for Overall Wholeness and Wellness

Berberine is an ammonium salt that occurs in plants like barberry (Berberis vulgaris), Oregon grape (Berberis aquafolium) and tree turmeric (Berberis aristata). Others without the berberis prefix include Amur cork tree, Californian poppy, and prickly poppy. It exists in the bark, roots, stems, and rhizomes of the various plants.
It is yellow in color and was initially used to dye things like leather, wool, and even wood. It was traditionally used as a dietary supplement and medicine against bacterial infections, yeast, fungal infections, and parasites.

Uses
It has been seen as a good treatment for trachoma, a bacterial infection that afflicts the eye and may cause blindness. It is also present in some eye drops for the treatment of eye conditions.
Due to its antibiotic properties, some people apply it topically on the skin to treat burns and other injuries. It is said to kill bacteria thus reducing the occurrence of an infection in the affected area, such as hyaluronic acid.
Congestive heart failure exhibits a weak heartbeat. Berberine has been found to increase the strength and activity of the heart meaning an improvement in the condition. This, in turn, improves the quality of life for the patient and also increases their mortality. This occurs when Berberine is paired with prescription drug therapy.
Studies have been conducted on both animals and humans and they revealed that berberine has an effect on blood glucose. It was found to reduce blood sugar by reducing insulin resistance. This greatly improves diabetes in a patient.
A recent study unearthed the ability of Berberine to curb damage to brain molecules from oxidation. It does this by inhibiting the action of the enzymes that break down memory molecules in the brain. It also reduces the number of peptides that may interfere with memory function and lowers lipids that may inhibit blood flow to the brain. As a result, it may also be able to keep Alzheimer’s disease at bay.
It helps in the reduction of total blood cholesterol and bad (LDL) cholesterol as well. This improves weight loss possibilities, heart health, and general health.
Other studies conducted showed that it could also reduce inflammation, improve bone density, reduces the spread of cancer cells and even protect you from brain damage. It tackles almost all the major problems that may afflict the human body thus ensuring great health.

Precautions
Pregnant women and those that are nursing should not take this compound because it may affect the unborn child or the nursing child respectively.

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Yohimbine and Fat Loss

Aside from the well-known and researched sexual benefits yohimbine offers, people have been experimenting with this drug to reach other kinds of goals. The biggest alternative use for yohimbine is definitely for its fat loss effects. The fitness community has been experimenting with yohimbine thoroughly ever since the standardized hydrochloride version came out into the market. Since then, there has been a lot of individual reporting on the effects of yohimbine, and it’s important to know these results if you plan on creating your own yohimbine “stack”.

Most people take yohimbine to get rid of fat repositories which are tricky to simply work off using exercises. Usually, these areas are located in the lower abdomen for males or around the thighs and hips for women. Some people like to combine fasting with yohimbine to restrict carbs and introduce a fat-burning chemical at the same time to burn fat pretty quickly. One of the things which are pretty universal with people who take yohimbine as a fat-burning chemical is that these people are already fairly lean. It is not advisable for obese individuals to take yohimbine supplement for fat loss as it works best to get rid of final troublesome areas rather than fat in general.

So, now that you know who does this kind of thing and why you are probably curious about the science behind yohimbine. This chemical works by binding to alpha-2 receptors on the fat cells. These receptors tell the fat cell to be more resilient to breaking down. Stubborn fat cells have more of these receptors on them, which is what makes them so hard to break down. Yohimbine comes in and disables this resilience action, which allows the fat cells to dissipate. In addition to this action, Yohimbine dilates your blood vessels which allows appropriate circulation to reach these forgotten fat reserves.

When it comes to consuming yohimbine, there are a few things to keep in mind. Although some people like to purchase raw Yohimbe bark herbal extract, the best way to take it is through the standardized yohimbine hydrochloride form. This is the form that has undergone all of the testings, and you will know what lies in each and every tablet. Taking yohimbine hydrochloride with caffeine is a good way to get extra fat-burning effects and appetite suppression. Be careful with this combination though – if you have any heart problems, it is not advised.

A few things to remember are that insulin completely blocks the effects of yohimbine, so it is imperative that you take the compound either while fasted or while you have a low blood sugar level. For the best effect, take yohimbine on an empty stomach or many hours after eating your last meal. If you just can’t avoid sugar, you can try to take yohimbine and hyaluronic acid after beginning a workout that drastically reduces your blood sugar levels. If you follow all of these tips, I’m sure yohimbine will help you finally get that well-shaped body you’ve always been looking for.

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Vine Tea Extracts – The New Vitamin P!

Vine tea extract can help you get rid of all fatal diseases like obesity, hypertension, heart problems, memory loss, blood pressure, hepatitis and many other similar and related health issues. This natural product like dihydromyricetin can help you remain fit and manage even the most stressful situations without taking any drugs or alcohol.

Vine tea extract is mainly used these days for regulating blood flow and empowering the liver. It has been named as ‘Vitamin P’ due to its ability to regulate blood flow. As a result of this, it is beneficial for all body functions like the digestive system and respiratory system. It regulates the glucose and lipid profile as well. Further researches have uncovered its properties as being an anti-bacterial and anti-tumor herb.

Regular usage of vine tea extract helps to reduce hypertension from the body. This natural extract also has neuroprotective aspect, which prevents its users from having Alzheimer’s disease, Parkinson’s disease etc. Recent research has found this herb as an effective tool for the treatment of alcoholism.

Vine tea extract is basically a Chinese native herb, found mainly in warmer climates all along the Chinese peninsula. It was initially used to make tea for treating several common diseases. We have extracted it from natural vine tea leaves, so that it can be used for getting its complete modern and old benefits uncovered so far.
At the most primitive level, the leaves were used to extract tea to treat the common cold and fever. However, later it was found that by its usage, symptoms of pain and swelling are also reduced. Hepatitis patients have observed improved health with its usage. This extract acts as an appetite suppressant and has a mildly sweet taste so that it leaves a nice and fresh breath to your mouth. Due to this, a person does not feel hungry and this herb becomes a weight loss agent.

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Polyphenols Extract – Hawthorn Extract

1. Hawthorn extract is extracted from hawthorn fruit of hawthorn and hawthorn as raw material.
2, the main chemical components: hawthorn fruits are mainly anthocyanidins, flavonoids, three terpenoids, fatty and aromatic acids, organic amine compounds: acetylcholine, trimethylamine, ethylamine, isoamylamine, and sugar, sorbitol, P gluten, adenosine, pectin, thirty alkanes, Hu. Radish and a lot of vitamin C and some trace elements.

3. Effect of the hawthorn extract
(1) Digestive function: Hawthorn is a traditional medicine to eliminate meat. Modern studies have shown that Hawthorn contains vitamin C, vitamin B, carotene and a variety of organic acids. Oral administration can increase the secretion of digestive enzymes in the stomach, enhance the activity of enzymes and promote digestion. It is reported that Hawthorn alcohol extract has a two-way regulating effect on stimulated gastric smooth muscle activity in rats. It shows that Hawthorn can adjust the gastrointestinal dysfunction obviously and achieve the effect of the invigorating spleen and be eliminating food. Hawthorn fatty hyaluronic acids can also promote the decomposition of fat, hawthorn acid can increase the activity of proteolytic enzymes, help digestion.

(2) Hawthorn’s cardiovascular prophylaxis and treatment:

(1) hypotensive effect: hawthorn extracts have certain cardiac effects on toad heart. Low dose injection had a hypotensive effect on anesthetized rabbits and mice. The principle of hypotension is mainly to dilate the peripheral blood vessels.

(2) The effect of reducing blood lipid and preventing atherosclerosis: modern studies have proved that the different extraction parts of hawthorn have a positive effect on various high fat models caused by different animals. Hawthorn can increase the high density lipoprotein (HDL) and lower the low density lipoprotein (LDL). It is beneficial to clear the excess cholesterol in the peripheral tissue and improve the lipid metabolism in the body. Hawthorn and Hawthorn flavonoids extract can significantly reduce the blood lipids of experimental hyperlipidemia rabbits and young rats, and have a therapeutic effect on experimental atherosclerosis.

(3) the effect of strong heart and anti-angina pectoris: Hawthorn has the effect of enhancing muscle contractile force, increasing cardiac output and slowing down rhythm of heart. The extract of hawthorn and its leaves can increase myocardial contractility related to concentration, do not affect cardiac rhythm, shorten the time of atrioventricular conduction, and prolong effective refractory period related to concentration.

Hawthorn also has the function of expanding coronary artery, increasing coronary flow and reducing oxygen consumption of myocardium. Hawthorn extract and hydrolysate had obvious antispasmodic effects on rabbit blood vessels. The results of its standard pharmacology and clinical trials indicate that it will serve as a substitute for synthetic drugs and become a new choice for plant treatment of chronic heart failure.

(4) anti-arrhythmia effect: Hawthorn extract has a strong effect on the arrhythmia caused by intravenous injection of aconitine, and the main effect is hawthorn flavonoids and saponins. Intravenous injection of hawthorn extract can prevent arrhythmia induced by injection of Pituitrin in rabbits.

Inhibition of platelet aggregation and antithrombotic effect: the total flavonoids of effective components in Hawthorn have an increasing effect on platelets and erythrocyte electrophoresis, which can reduce the electrophoresis time significantly, improve the hemodynamics, increase the surface charge of red cells and platelets, increase the repulsion between cells and accelerate them in the blood. Flow rate promotes axial flow, reduces edge flow and aggregated adhesion.

(4) Anticancer effect: Hawthorn extract can block benzyl nitrosamine and induce cancer in vivo.

(5) Improve the immune function of the body: the results of the experiment confirm that the injection of hawthorn extract has a significant effect on the content of serum lysozyme, the titer of serum agglutination antibody, the T lymphocyte of heart and blood, the rate of Erose ring formation and the conversion of T lymphocyte in the heart and blood.

(6) Antibacterial effect: the experimental study showed that the Hawthorn and ethanol extracts were used for bacilli , Shigella, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Bacillus anthracis, Streptococcus, diphtheria, Bacillus typhi, Bacillus mutants, Staphylococcus aureus, Candida albicans Bacteria and Escherichia coli have antibacterial effect E4 o.. Clinically, it is used as a plant disinfectant. It is used for external application of fresh or cooked products to treat frostbite infection and ulcers, and achieves good results.

(7) Analgesic effect: Hawthorn can relax the blood vessels, help relieve local blood stasis, and contract the uterus and promote the recovery of the uterus.

(8) Protection of retina: hawthorn, Lycium barbarum and jujube decoction can improve the tolerance of CS2 infected rabbits to CS2, and protect the retina to a certain extent.

(9) Other functions: Hawthorn has the function of diuresis, phlegm and cough, which can be used to treat chyluria, hiccup, vocal polyp, soft tissue injury of the lower extremities, bone marrow, psoriasis, neurodermatitis, eczema and so on. It can also be used for weight loss.

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Decolorization of Natural Plant Extracts

At present, there are many methods and processes used in decolorizing traditional Chinese medicine, but they can be classified by the following methods.

First, remove the solubility of pigments in different solvents.

This is the most commonly used, the simplest and the less effective method.

1. Water extraction and alcohol precipitation: a small number of water-soluble pigments can be removed.

Alcohol extraction and water precipitation: most fat-soluble pigments can be removed.

2. Acid-base precipitation method: for example, when the impurity pigment is some flavonoid, anthraquinone and other phenolic acidic components, it can adjust the following PH3, and its precipitation.

Two, Remove the pigments in the two-phase solvent.

For example, when the impurity pigment is some flavonoid, anthraquinone and other phenolic acidic components, it can be adjusted by PH to more than 12, using organic solvent extraction method. At this time, the pigment is in the form of dissociation, and it is not suitable to be extracted.

Three, Separation according to the difference between pigment and active ingredients

1. physical adsorption: (adsorption force is the intermolecular force)

(1) polar adsorbents, such as silica gel and alumina. The hydrophilic pigment can be removed.

(2) nonpolar adsorbent: such as activated carbon, pulp, talcum powder and diatomite. Lipophilic pigments can be removed.

Activated carbon is an excellent adsorbent. It has strong adsorption capacity for pigments, bacteria, pyrogen and other impurities, and it also has the function of filtering.

There are a large number of micropores and gaps in it, with a surface area of 200-500m2/g.

Adsorption principle: most pigments are easily absorbed because of their conjugated double bond structure.

Methods of use: cold adsorption, thermal adsorption, carbon layer filtration and column chromatography.

2. Chemisorption:

(1) For example, alkaline alumina can be used to remove some phenolic acids such as flavonoids and anthraquinones.

(2) Ion exchange resin method: for example, flavonoids, anthraquinones, and other phenolic acid pigments can be removed by anion exchange resin.

3. Semi-chemical adsorption: polyamide and macroporous resin. The adsorption principle is hydrogen bonding, and the macroporous resin has some Vander Ed Ley effect.

Polyamides can form hydrogen bonds with phenolic carbonyl groups and phenolic hydroxyl groups of flavonoids. Hydrogen bonds can also be formed by the free amino groups on the amide bond with carbonyl groups on the quinones and fatty acids.

Four, precipitation method to remove pigment

Representative substance: lime milk.

The usual concentration: 20% – 30%.

The principle of decolorization: calcium ions in lime milk combine with the effective components and impurities in the liquid to form calcium chelates and calcium salts. Under the action of sulphuric acid, the calcium salts of flavonoids, anthraquinones, phenols, saponins, some alkaloids and calcium ions can be decomposed and dissolved into water. But tannins, some proteins, organic acids, polar pigments, polysaccharides and so on cannot be broken down.

Five, Removal of pigments by flocculant method:

1. The commonly used flocculants are as follows:

(1) gelatin type: tannin affects the stability of liquid and is easy to discoloration. Gelatin and tannin administrative complex can be used to precipitate together with suspended particles in water.

(2) ZTC1+1 natural clarifying agent:
It is divided into four types:
Type I: protein deproteinized

Type II: decolorization clarification

Type III: Traditional Chinese medicine oral liquid and granule type, can replace alcohol precipitation method, to remove unstable ingredients and filter aid.

Type IV: injection type, mainly to improve clarity.

(3) 101 juice clarifier:

(4) Chitin and chitosan: chitin is acetylated from chitin. They are natural cationic flocculants.

2. Factors affecting the clarification effect:

(1) The amount of clarifying agent

(2) The preparation concentration and order of the clarifying agent

(3) The concentration of the liquid itself

(4) The effect of temperature on flocculation

(5) The effect of PH on the liquid

(6) Influence of stirring speed and stirring time

(7) The effect of flocculation and precipitation time

Six. Membrane separation and removal of pigments

The most commonly used ultrafiltration technology

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Resveratrol Can Reduce Oxidative Stress in Patients With Type II Diabetes Mellitus

Recently, researchers at the Tohoku University Japan cherry Medical Center found that resveratrol can reduce the oxidative stress and relieve arteriosclerosis in patients with type II diabetes.

In this study, the researchers recruited 50 patients with type II diabetes, randomly divided into two groups, a group of resveratrol oral supplements, and a placebo group for 12 weeks.

The results showed that the atherogenic index and oxidative stress in the resveratrol group were significantly reduced, while the body weight and BMI index also decreased slightly. At the same time, the new shrinkage pressure also decreased significantly.

The researchers believe that arteriosclerosis shows a reversible vascular disorder that is a good marker for vascular injury and has good benefits for the evaluation of resveratrol. In addition, the reduction of oxidative stress after resveratrol supplementation is also considered to help improve the symptoms of diabetes.

Researchers believe that the reduction of oxidative stress and weight loss may be related to the mechanism of atherosclerosis remission. The underlying mechanism is that resveratrol can improve endothelial function.

The researchers say that although resveratrol supplements can improve oxidative stress and arterial function in patients with type II diabetes, this study is still in a small, short-term study, and the long-term use of resveratrol supplements has not been known. A larger, longer-term, double-blind crossover trial is needed to confirm its role.

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The Natural Structure of Plant derived Foods

Maintaining the natural structure of plant-derived foods limits the exposure of fat to digestive enzymes in the gastric juice.

A study from the Quadram Institute and King’s University in London, the University of Surrey and the University of Messina found that maintaining the natural structure of a plant-derived food limits the exposure of fat to the digestive enzymes in the stomach, which inhibits the body’s absorption of fat.

The researchers say that if natural plant structure can maintain the body’s level of absorption of fat, it will help reduce body fat accumulation, help control weight and reduce the potential for cardiovascular disease.

Previous studies have found that ingestion of intact almond does not cause weight gain, although almond has a fat content of 50%. Accordingly, the researchers designed a test to explore how different almond processing methods affect the body’s intake of almond fat.

In the study, the researchers gave participants 2 almond pancake, one almond block made of the 2mm size and the other using almond powder. Almond cake is normally chewed and eaten in the dynamic stomach model. The model can accurately simulate the physiological and chemical conditions of the small intestine and observe the release of fat.

60 minutes after the food was put into the model, the researchers found that 40% of the fat in Almond pancake made from almond powder had been released, and only 6% of the fat was released in the almond block. After digestion for 9 hours in the small intestine, 97% of the fat in the almond powder was released, and only 60% of the fat in the almond block was released.

The researchers believe that the preservation of the natural structure of the plant source food 10-hydroxycamptothecin can maintain the integrity of the cell wall to a greater extent, thereby limiting the release of fat in the cells and reducing the absorbability and utilization of fat.

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Vitamin D Intake can Reduce The Risk of Severe Asthma Attacks

There are about 300 million asthmatic patients worldwide, and 400 thousand patients die from asthma each year.

Published in the Lancet Respiratory Medicine magazine, a study by researchers at Queen Marie’s College of University of London showed that the intake of vitamin D supplemental food can reduce the risk of severe asthma attacks.

The study and analysis of data from 955 patients with asthma, who took vitamin D supplemental food while receiving regular treatment, showed a 30% reduction in the degree of need for steroid intake, and a 50% decrease in the necessary severe attacks in hospitalization.

In particular, at the beginning of the experiment, patients with low levels of vitamin D had a more significant intake of nutritional supplements, with a 55% reduction in the degree of steroid seizures and no side effects in the intake of nutritional supplements.

The results showed that vitamin D has the function of enhancing the immune response to respiratory viruses and calming the respiratory tract inflammation.

The researchers said the survey was mainly targeted at mild to moderate adult asthmatics, while further investigation was needed for the impact of children and severe adult patients.

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What are The Side Effects of Leonurine?

Leonurus is a plant, but also a traditional Chinese medicine, Leonurine has a long history, especially for the treatment of women’s disease, such as the treatment of irregular menstruation, postpartum diseases and so on, can also play the beauty of beauty, acne efficiency, deeply loved by women friends.

Toxic and side effects

The toxicity of Leonurus was very low. The injection of Leonurus Leonuri injection to mice was 30 ~ 60g, and the total alkaloid of Leonurus Leonuri was injected into the mice by intravenous injection, and half of the lethal dose was 572.2 + 37.2mg. Leonurine in the abdominal cavity, and each time was 2mg for 4 days without obvious adverse reaction. The total alkaloid of Leonurus Leonuri was injected 30mg/d under rabbit skin for 2 weeks. No significant effect was observed on food, body temperature and defecation. Feeding with 50% motherwort powder feed to adult rats for 80 days did not show toxicity or fertility change.

The role of the cardiovascular system

Low dose of Herba Leonuri increased contractility in isolated frog heart, and inhibited it in a large dose. This inhibition may be due to the excitation of vagal nerve terminals. Use of Leonurine (2mg) injection in the intravenous anesthesia of the cat, that is, the drop of blood pressure, a few minutes after the recovery, this moment temporary blood pressure drop phenomenon, after the vagotomy of the vagus can still be found, if the first use of atropine, and then injection of Leonurine, the blood pressure drop is not as significant as before, it can be known that Leonurine. The effect of lowering blood pressure is not caused by vagotomy, but may be stimulated by vagal nerve terminals.

The role of the respiratory center

Herba Leonuri had direct excitation, and the respiratory frequency and amplitude increased significantly after intravenous injection of Leonurus alkaloids in cats, but at large doses, respiration was turned from excitement to inhibition and became weak and irregular. After cutting off both sides of the nerve, there is still no respiratory excitation.

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5 Incredible Health Benefits of Giant Knotweed

Giant knotweed showed extensive antioxidant properties, such as LDL cholesterol oxidation and lipid peroxidation. Resveratrol can also help cardiovascular health and blood circulation, relieve pain, clear away heat and remove dampness, eliminate toxin and eliminate phlegm. Other ingredients include Dan anthrone, emodin and rhein all have anti-inflammatory, anti arthritis and anti microbial activities.

1. antipyretic and analgesic effects
Resveratrol plays a therapeutic effect in a variety of ways. It shows a certain amount of antipyretic and analgesic activity, as shown in complete mice and rats. Its extract shows that it can give gastric mucosa resistance to stress ulcer caused by suppressed gastric secretion without affecting blood pressure.

2. anticancer, antimutagenic ability
Resveratrol, as an antioxidant, antimutagen and anti-inflammatory agent, shows the chemopreventive capacity of cancer. It can also induce differentiation of human promyelocytic leukemia cells (anti proliferation) and inhibit the development of breast precancerous lesions. Resveratrol also inhibits protein tyrosine kinase, a tyrosine phosphorylated substance. The kinase is contained in the cytoplasmic information transduction of mitotic regulatory cells. Inhibition of protein tyrosine kinase by resveratrol may play an antimutagenic role by blocking the function of the kinase.

3. prevention of heart and liver injury
The deposition of resveratrol could inhibit the liver triglyceride and cholesterol. It can also increase aspartate aminotransferase and alanine aminotransferase levels by inhibiting the lipid peroxidation in mice liver. The analysis of these two enzymes in the serum gave good diagnostic information for heart and liver injury.

4. antithrombotic function
Resveratrol inhibits lipoxygenase biosynthesis. The enzyme exists in white blood cells, heart, brain, lung and spleen. Therefore, resveratrol can prevent the formation of blood clots in blood vessels. It also inhibits platelet aggregation after clonidine antihypertensive treatment.

5. improve the immune system activity in wound treatment
Giant knotweed can also promote scald healing by enhancing the immune system. Luo studied the efficacy of resveratrol in restoring cellular, humoral and non-specific immune functions in scalded mice. Controlled use of resveratrol provides a drug dependent immunomodulatory effect. The study of mice with severe scald in different degrees showed that resveratrol could restore its damaged function, such as response to antigen signal, proliferative ability, iinterleukin-II synthesis and antibody synthesis through lymphocyte. After the treatment of severely burned animals, the neutrophil level and neutrophil adhesion rate of the controlled resveratrol were recovered to the normal level, and the survival time was prolonged.

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